Our Research
Reliable and high-throughput humanised & personalised models
Human Brain-on-chip and organoid for infection study
Aim: Utilise lab-grown mini-brain model to investigate pathogen-host interaction in human context
Research focus: Working on human brain organoid generation and screening the diverse pathogen (neurotropic vs. inflammation-driven vs. systemic), analyse the pathogen infection behavior of neurons
Brain-body circulation-on-chip
Aim: Develop microfluidic device design for brain organoid to multi-organ crosstalk
Research focus: Focusing on new microfluidic device fabrication to cultivate 3D organoids including brain, gut, pancreas, lung, kidney, liver, circulatory system to reveal multi-organ level communications
Brain inter-regional communications and neural circuits
Aim: Investigate diverse regions of brain organoids and their neural plasticity
Research focus: Focusing on the different regions of 3D brain tissue generation and their communications in cell to organ & functional level, especially focusing on the neural circuits and plasticity
Extracellular Matrix (ECM) and 3D Brain development/organogenesis
Aim: Investigate diverse types of ECM hydrogel and brain develop in tissue scale
Research focus: Focusing on the bioprinting and material technology to apply on 3D brain organoid generation and investigate ECM-cell interaction & morphological stimulations on brain embryogenesis
High-throughput drug screening platform as humanised pre-clinical model
Aim: Develop gradient & high-throughput chips for drug screening utilising brain organoids
Research focus: Focusing on the design of high-throughput microfluidic chip fabrication for one-stop 3D brain organoid generation and drug screening to screen multiple drug concentration/type
Neuroinflammatory system-on-chip & Metabolomics
Aim: Generate a sophisticated neuroinflammation model in brain organoid-on-chip
Research focus: Focusing on new microphysiological platform fabrication (µm-mm-cm size) to generate neuroinflammatory cells (microglial, astrocyte) in the 3D brain organoid surrounding to monitor the pathogenic condition (e.g., dementia, traumatic brain injury, stroke-thrombosis) driven neuroinflammation and following impacts on the neurons & neuronal network